SPRO Spero Therapeutics, Inc.
Biotechnology NasdaqGS
SELL SPRO is showing a Bearish technical setup (SELL, 74% confidence) — RSI 34.0, MACD below its signal line. Key support $0.98, resistance $1.09.
Based on end-of-day data, updated after each U.S. market close. Not investment advice.
Trading Signals (SPRO)
How these signals performed on SPRO
Historical occurrences of each signal on this stock since January 2024, and the forward return that followed. Small samples are shown as-is—a handful of events is not a track record.
| Signal | Horizon | Times | Win rate | Median |
|---|---|---|---|---|
| RSI oversold recovery | 5d | 9 | 44.4% | 0.00% |
| 10d | 9 | 33.3% | -2.38% | |
| 20d | 8 | 12.5% | -8.41% | |
| RSI overbought reversal | 5d | 6 | 16.7% | -6.50% |
| 10d | 6 | 33.3% | -3.42% | |
| 20d | 6 | 50.0% | -1.42% | |
| MACD golden cross | 5d | 21 | 42.9% | -0.42% |
| 10d | 21 | 23.8% | -4.56% | |
| 20d | 21 | 14.3% | -6.90% | |
| MACD death cross | 5d | 20 | 20.0% | -2.47% |
| 10d | 20 | 35.0% | -2.62% | |
| 20d | 20 | 35.0% | -3.13% | |
| MA20/MA60 golden cross | 5d | 4 | 25.0% | -4.22% |
| 10d | 4 | 50.0% | +6.06% | |
| 20d | 4 | 50.0% | +5.96% | |
| MA20/MA60 death cross | 5d | 4 | 50.0% | +0.96% |
| 10d | 4 | 25.0% | -4.32% | |
| 20d | 4 | 25.0% | -5.39% |
Sample period from 2024-01-01 to the latest close. Returns are gross of transaction costs and do not account for liquidity. A small number of occurrences is not statistically meaningful. Full method and market-wide results: backtest.php. Not investment advice.
Overall Signal
SELL
Strong sellish signal based on multiple indicators.
Key Price Levels
Support Levels
- Strong Support $0.88
- Medium Support $0.93
- Weak Support $0.98
Resistance Levels
- Weak Resistance $1.09
- Medium Resistance $1.15
- Strong Resistance $1.21
Stop Loss Suggestions
- Conservative $1.18
- Moderate $1.12
- Aggressive $1.18
Analyst Ratings
Current Rating
Signal Indicator
| Indicator | Signal | Strength | Timeframe |
|---|---|---|---|
| Moving Averages | SELL |
|
Short & Medium Term |
| Oscillators | SELL |
|
Short Term |
| Trend Indicators | SELL |
|
Medium Term |
| Volume Indicators | NEUTRAL |
|
Short & Medium Term |
| Support/Resistance | NEUTRAL |
|
Short Term |
Price Outlook Price Target Probabilities (SPRO)
Quarterly Outlook :
2026-11-04
Bullish Scenario
from current 17.09%
Strong upward momentum and confirmed bullish trend, with potential for significant price appreciation. Indicators point to sustained buying pressure. ADX (37.34) indicates a strong trend. -DI > +DI suggests strong bearish directional bias. RSI (34.05) is in bearish territory, indicating downward momentum. MACD line (-0.20) is above Signal line (-0.24) (bullish crossover), confirming upward momentum. Current Weekly ATR is 0.10, indicating the average weekly price range.
2026-11-04
Base Scenario
from current -3.42%
Price is likely to continue its moderate trajectory, reflecting underlying market conditions and historical volatility. Indicators suggest a balanced outlook. ADX (37.34) indicates a strong trend. -DI > +DI suggests strong bearish directional bias. RSI (34.05) is in bearish territory, indicating downward momentum. MACD line (-0.20) is above Signal line (-0.24) (bullish crossover), confirming upward momentum. Current Weekly ATR is 0.10, indicating the average weekly price range.
2026-11-04
Bearish Scenario
from current -21.37%
Increased selling pressure and potential for a significant price correction or downtrend. Indicators suggest waning bullish momentum or strengthening bearish forces. ADX (37.34) indicates a strong trend. -DI > +DI suggests strong bearish directional bias. RSI (34.05) is in bearish territory, indicating downward momentum. MACD line (-0.20) is above Signal line (-0.24) (bullish crossover), confirming upward momentum. Current Weekly ATR is 0.10, indicating the average weekly price range.
Annual Outlook
2026-11-04
Bullish Scenario
from current 34.19%
Long-term bullish trend with strong fundamental catalysts and sustained institutional buying. Expect significant capital appreciation over the year. ADX (37.34) indicates a strong trend. -DI > +DI suggests strong bearish directional bias. RSI (34.05) is in bearish territory, indicating downward momentum. MACD line (-0.20) is above Signal line (-0.24) (bullish crossover), confirming upward momentum. Current Weekly ATR is 0.10, indicating the average weekly price range.
2026-11-04
Base Scenario
from current -6.84%
Steady long-term growth consistent with market and industry averages. Price expected to follow a typical growth trajectory. ADX (37.34) indicates a strong trend. -DI > +DI suggests strong bearish directional bias. RSI (34.05) is in bearish territory, indicating downward momentum. MACD line (-0.20) is above Signal line (-0.24) (bullish crossover), confirming upward momentum. Current Weekly ATR is 0.10, indicating the average weekly price range.
2026-11-04
Bearish Scenario
from current -42.74%
Long-term bearish trend with significant headwinds from economic factors, industry disruption, or company-specific issues. Expect notable price depreciation. ADX (37.34) indicates a strong trend. -DI > +DI suggests strong bearish directional bias. RSI (34.05) is in bearish territory, indicating downward momentum. MACD line (-0.20) is above Signal line (-0.24) (bullish crossover), confirming upward momentum. Current Weekly ATR is 0.10, indicating the average weekly price range.
Technical Analysis (SPRO)
Trend Identification
EMA
Exponential Moving Average
Current price (1.04) is below both Short MA (1.13) and Long MA (1.35). This indicates strong bearish momentum. Short MA (1.13) is below Long MA (1.35), a bearish crossover ('Death Cross' if it's a significant period). This indicates a downward trend. All MAs are in bearish order (Price < Short MA < Long MA < Very Long MA 1.84). This is a strong bearish alignment. Consider short positions. Use the MAs as dynamic resistance levels.
MACD
Moving Average Convergence Divergence
MACD line is crossing the Signal line. This is a crucial point, signaling a potential trend change. Monitor closely. Both MACD and Signal lines are below the zero line, reinforcing bearish momentum (bearish territory).
ADX
Average Directional Index
ADX (26.50) indicates a strong trend is present. -DI (27.59) is above +DI (15.54), suggesting a bearish directional bias. This combination points to a strong downward trend. Consider taking short positions, as the strong downward trend is confirmed.
Momentum Measurement
RSI (2026-11-04)
Relative Strength Index
RSI (34.02) is in the bearish territory, but not yet oversold. This indicates downward momentum. Monitor for continuation or signs of strength.
OBV (2026-11-04)
On-Balance Volume
OBV (-16109088.00) is flat, indicating indecision or a balanced market. Price is relatively stable. OBV movement will indicate hidden accumulation/distribution.
Stochastic (2026-11-04)
Stochastic Oscillator
Stochastics (%K: 9.21, %D: 28.41) are in the neutral zone (between 20 and 80). A bearish crossover (%K below %D) is observed. This indicates downward momentum. Be cautious if it's already in the oversold region.
CCI (2026-11-04)
Commodity Channel Index
CCI (-144.76) is below -100. This suggests a strong downward momentum and an oversold condition. Consider buying or looking for long entries cautiously. Confirm with price action; if price is making lower lows, momentum is strong. Look for rallies to enter short.
Volatility Measurement
ATR (2026-11-04)
Average True Range
Current ATR is 0.0600. ATR indicates average volatility. Market conditions are relatively stable.
Bollinger Bands (2026-11-04)
Volatility Bands
Current price (1.04) is within the Bollinger Bands (1.03 - 1.23). This suggests the price is trading within its typical volatility range. Price is below the Middle Band (1.13), indicating short-term bearish bias. Bollinger Bands are wide. This indicates high volatility. Prices tend to revert to the mean after extended periods of high volatility.
Risk Management & Potential Reversals (SPRO)
SAR (2026-11-04)
Parabolic Stop and Reverse
SAR points above price indicate bearish trend. Current SAR at 1.18 is 13.46% from price. Consider SAR as a potential take-profit level or to confirm a downtrend.
Stochastic (2026-11-04)
Oversold
Stochastic is in oversold territory (9.2). Monitor for potential bullish crossover or movement above 20, which could signal a reversal. Current crossover status: Bearish.
RSI (2026-11-04)
Reversal Perspective
Current RSI level is in neutral territory. No RSI divergence detected. Current RSI level doesn't suggest imminent reversal.
Bollinger Bands (2026-11-04)
Reversal Perspective
Bollinger Bands are widening, indicating high volatility and potential strong trend continuation.Price is in the lower half of the bands, suggesting a bearish bias.No indication of imminent volatility expansion or reversal.
Holder List Top 20 (SPRO)
| Holder Name | Holder Type | Shares | Pct. Held | Date Reported |
|---|---|---|---|---|
| Anson Funds Management LP | INSTITUTIONAL | 3798932 | 6.8% | 2025-03-31 |
| Pfizer Inc | INSTITUTIONAL | 2362348 | 4.23% | 2025-03-31 |
| Vanguard Group Inc | INSTITUTIONAL | 1763620 | 3.15% | 2025-03-31 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | MUTUALFUND | 1166116 | 2.09% | 2025-03-31 |
| Renaissance Technologies, LLC | INSTITUTIONAL | 970907 | 1.74% | 2025-03-31 |
| Alphabet Inc. | INSTITUTIONAL | 889979 | 1.59% | 2025-03-31 |
| Murchinson Ltd. | INSTITUTIONAL | 873910 | 1.56% | 2025-03-31 |
| Acadian Asset Management. LLC | INSTITUTIONAL | 871212 | 1.56% | 2025-03-31 |
| Adar1 Capital Management, LLC | INSTITUTIONAL | 801277 | 1.43% | 2025-03-31 |
| VANGUARD INDEX FUNDS-Vanguard Extended Market Index Fund | MUTUALFUND | 587342 | 1.05% | 2025-03-31 |
| Geode Capital Management, LLC | INSTITUTIONAL | 524869 | 0.94% | 2025-03-31 |
| Blackrock Inc. | INSTITUTIONAL | 482082 | 0.86% | 2025-03-31 |
| Fidelity Concord Street Trust-Fidelity Extended Market Index Fund | MUTUALFUND | 239171 | 0.43% | 2025-04-30 |
| Fidelity Concord Street Trust-Fidelity Total Market Index Fund | MUTUALFUND | 108991 | 0.19% | 2025-04-30 |
| Bridgeway Funds, Inc.-Ultra-Small Company Market Fund | MUTUALFUND | 104800 | 0.19% | 2025-03-31 |
| iShares Trust-iShares Micro-Cap ETF | MUTUALFUND | 92411 | 0.17% | 2025-04-30 |
| Fidelity Concord Street Trust-Fidelity Series Total Market Index Fund | MUTUALFUND | 59656 | 0.11% | 2025-04-30 |
| Bridgeway Funds, Inc.-Omni Small-Cap Value Fund | MUTUALFUND | 50000 | 0.09% | 2025-03-31 |
| SCHWAB CAPITAL TRUST-Schwab Total Stock Market Index Fund | MUTUALFUND | 28565 | 0.05% | 2025-01-31 |
| Fidelity Concord Street Trust-Fidelity Nasdaq Composite Index Fund | MUTUALFUND | 19478 | 0.03% | 2025-04-30 |